- Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve-Dependent Regulation of NKG2D and CCR5.
Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve-Dependent Regulation of NKG2D and CCR5.
Cancer research (2017-01-14)
Yanfang Song, Yu Gan, Qing Wang, Zihong Meng, Guohua Li, Yuling Shen, Yufeng Wu, Peiying Li, Ming Yao, Jianren Gu, Hong Tu
PMID28082402
ABSTRACT
Mice housed in an enriched environment display a tumor-resistant phenotype due to eustress stimulation. However, the mechanisms underlying enriched environment-induced protection against cancers remain largely unexplained. In this study, we observed a significant antitumor effect induced by enriched environment in murine pancreatic cancer and lung cancer models. This effect remained intact in T/B lymphocyte-deficient Rag1
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