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Merck

Targeted and multifunctional arene ruthenium chemotherapeutics.

Dalton transactions (Cambridge, England : 2003) (2011-08-23)
Gregory S Smith, Bruno Therrien
ABSTRACT

The introduction of multifunctionalities for tumour targeting is becoming a popular strategy toward the development of new therapeutic agents. In particular, the multifaceted potential of ruthenium(II)-arene complexes show great promise as chemotherapeutics. An ever-increasing number of papers dealing with the integration of ruthenium complexes with biologically active molecules to derive bioorganometallic molecules of chemotherapeutic significance have been published in recent years. This perspective review presents a short overview of multifunctional ruthenium-based drugs, especially those containing arene ruthenium complexes, with the emphasis on the combination of photosensitizers with ruthenium complexes for the preparation of novel multifunctional photodynamic therapy agents.

MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto

Sigma-Aldrich
Ruthenium, powder
Sigma-Aldrich
Ruthenium, powder, −200 mesh, 99.9% trace metals basis
Sigma-Aldrich
Ruthenium black
Ruthenium, Ruthenium, foil, 6x6mm, thickness 1.0mm, 99.9%
Ruthenium, Ruthenium, pellets, 5g, max. size 10mm, 99.9%
Ruthenium, Ruthenium, foil, 25x25mm, thickness 1.0mm, 99.9%
Ruthenium, Ruthenium, bar, 50mm x 2mm x 2mm, 99.9%
Ruthenium, Ruthenium, foil, 10x10mm, thickness 1.0mm, 99.9%
Ruthenium, Ruthenium, bar, 25mm x 2mm x 2mm, 99.9%
Ruthenium, Ruthenium, rod, 12.7mm, diameter 12.7mm, 99.9%
Ruthenium, Ruthenium, microfoil, disks, 10mm, thinness 0.1μm, specific density 122μg/cm2, permanent mylar 3.5μm support, 99.9%
Ruthenium, Ruthenium, pellets, 2.5g, max. size 10mm, 99.9%
Ruthenium, Ruthenium, microfoil, disks, 10mm, thinness 0.025μm, specific density 30.5μg/cm2, permanent mylar 3.5μm support, 99.9%