- Protecting group free glycosidations using p-toluenesulfonohydrazide donors.
Protecting group free glycosidations using p-toluenesulfonohydrazide donors.
Organic letters (2008-07-12)
Anna V Gudmundsdottir, Mark Nitz
PMID18616337
ABSTRACT
N'-Glycopyranosylsulfonohydrazides are introduced as glycosyl donors for protecting group free synthesis of O-glycosides, glycosyl azides, and oxazolines. Mono- and disaccharides containing a reducing terminal N-acetylglucosamine residue were condensed with p-toluenesulfonylhydrazide to give the desired beta- d-pyranose donors. These donors can be activated with NBS and then glycosidated with the desired alcohol or transformed to the oxazoline or glycosyl azide.
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