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Preparation of novel beta-cyclodextrin chiral stationary phase based on click chemistry.

Journal of chromatography. A (2007-12-07)
Yongping Zhang, Zhimou Guo, Jinxing Ye, Qing Xu, Xinmiao Liang, Aiwen Lei
ABSTRACT

A facile strategy based on click chemistry for preparation of the structurally well-defined native beta-cyclodextrin (beta-CD) based chiral stationary phase (CSP) was proposed. The beta-CD CSP was evaluated by enatioseparation of benzoin, trans-stilbene oxide, Troger's base, bendroflumethiazide, ketoprofen, chlorthalidone, three flavanone compounds and two beta-adrenergic blocking agents under reversed phase high performance liquid chromatography. The chromatographic results demonstrate the chiral separation ability of click beta-CD CSP and illustrate the usefulness of click chemistry in the preparation of beta-CD based CSP.

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Sigma-Aldrich
trans-Stilbene oxide, 98%
Sigma-Aldrich
cis-Stilbene oxide, 97%