- Bacterial biofilm inhibitors from Diospyros dendo.
Bacterial biofilm inhibitors from Diospyros dendo.
Journal of natural products (2006-01-31)
Jin-Feng Hu, Eliane Garo, Matt G Goering, Mark Pasmore, Hye-Dong Yoo, Tim Esser, Jennifer Sestrich, Peadar A Cremin, Grayson W Hough, Peter Perrone, Yin-Shi L Lee, Ngoc-Tram Le, Mark O'Neil-Johnson, John W Costerton, Gary R Eldridge
PMID16441080
ABSTRACT
One new (1) and four known (2-5) ursene triterpenes with potent inhibition of the formation of the bacterial biofilm Pseudomonas aeruginosa PA01 were obtained from Diospyros dendo using a high-throughput natural products chemistry procedure. These compounds were isolated as mass-limited samples. The miniaturization of the structure elucidation and dereplication was performed primarily utilizing a capillary-scale NMR probe.