SRP2147

CAR-LBD (101-348), GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• Sinonimo/i: CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• Codice UNSPSC: 12352202
• NACRES: NA.26

Proprietà

• Origine biologica: human
• Ricombinante: expressed in E. coli
• Saggio: ≥70% (SDS-PAGE)
• Forma fisica: frozen liquid
• PM: ~55.3 kDa
• Confezionamento: pkg of 10 μg
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• Concentrazione: 100 μg/mL
• Colore: clear; colorless
• N° accesso NCBI: NM_005122
• N° accesso UniProt: Q14994
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... NR1I3(9970)

Descrizione

Descrizione generale

The gene encoding this protein is localized on human chromosome 1q23.3.

Azioni biochim/fisiol

It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling.

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Stato fisico

Clear and colorless frozen liquid solution

Nota sulla preparazione

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable