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Merck
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SML0453

Sigma-Aldrich

TBPB

≥98% (HPLC)

Sinonimo/i:

1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

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About This Item

Formula empirica (notazione di Hill):
C25H32N4O
Numero CAS:
634616-95-8
Peso molecolare:
404.55
Numero MDL:
MFCD22666590
Codice UNSPSC:
12352200
ID PubChem:
329824732
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

DMSO: 5 mg/mL (clear solution; warmed)

Temperatura di conservazione

2-8°C

Stringa SMILE

Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45

InChI

1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)
CWPKTBMRVATCBL-UHFFFAOYSA-N

Azioni biochim/fisiol

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Ashwini Kumar et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 115(1), 3-10 (2015-07-30)
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline, i.e., dementia. The disease starts with mild symptoms and gradually becomes severe. AD is one of the leading causes of
Hidenori Hashimoto et al.
Scientific reports, 7(1), 17216-17216 (2017-12-10)
Ionic clathrate hydrates can selectively capture small gas molecules such as CO
Aleksei Furletov et al.
Sensors (Basel, Switzerland), 20(17) (2020-09-02)
Nowadays, analytical systems based on silver triangular nanoplates (AgTNPs) have been shown as good prospects for chemical sensing. However, they still remain relatively poorly studied as colorimetric probes for sensing various classes of compounds. This study shows that these nanoparticles
Shang-Chi Lin et al.
Scientific reports, 4, 6976-6976 (2014-11-14)
A good diagnostic procedure avoids wasting medical resources, is easy to use, resists contamination, and provides accurate information quickly to allow for rapid follow-up therapies. We developed a novel diagnostic procedure using a "cotton-based diagnostic device" capable of real-time detection
Leonardo M Dos Santos et al.
Journal of environmental management, 268, 110340-110340 (2020-05-10)
CO2 separation from natural gas is considered to be a crucial strategy to mitigate global warming problems, meet product specification, pipeline specs and other application specific requirements. Silica xerogels (SX) are considered to be potential materials for CO2 capture due
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Articoli

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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