SAB4200623

Anti-C9orf72 antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: 3110043O21Rik, AI840585, ALSFTD, C9orf72, FLJ11109, FTDALS, RGD1359108, RP23-307M2.1, zgc:100846
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 200
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Forma fisica: buffered aqueous solution
• PM: ~55 kDa
• Reattività contro le specie: human
• Concentrazione: ~1 mg/mL
• tecniche: immunoblotting: 0.3-0.6 μg/mL using whole extracts of T98G cells; immunocytochemistry: 4-6 μg/mL using SH-SY-5Y cells; immunohistochemistry: 10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon sections
• N° accesso UniProt: Q96LT7
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... C9orf72(203228)

Descrizione

Descrizione generale

C9orf72 (chromosome 9 open reading frame 72) is a DENN domain containing protein. It is expressed in neuronal cell lines. It has been reported that C9orf72 colocalizes with Rab proteins, which indicates its role in autophagy and endocytic transport pathways.

Chromosome 9 open reading frame 72 (C9orf72) gene is mapped to human chromosome 9p21.

Specificità

Anti-C9orf72 recognizes human C9orf72.

Immunogeno

synthetic peptide corresponding to the N-terminal region of human C9orf72

Applicazioni

Anti-C9orf72 antibody produced in rabbit may be used in:

• immunoblotting
• immunocytochemistry
• immunohistochemistry

Azioni biochim/fisiol

C9orf72 (chromosome 9 open reading frame 72) maintains a physical interaction with Rab proteins during autophagy, cellular trafficking and protein degradation. The cellular activities of the protein are not well defined. It has been reported that mutations of C9orf72 gene are associated with amyotrophic lateral sclerosis (ALS) with degeneration of upper and lower motor neurons in the brain, brainstem and spinal cord, leading to progressive paralysis and frontotemporal dementia.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Stoccaggio e stabilità

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable