R125
Anti-RANTES antibody produced in goat
affinity isolated antibody, lyophilized powder
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About This Item
Prodotti consigliati
Origine biologica
goat
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
lyophilized powder
Reattività contro le specie
human
tecniche
immunohistochemistry (frozen sections): suitable
neutralization: suitable
western blot: suitable
N° accesso UniProt
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CCL5(6352)
Categorie correlate
Descrizione generale
RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The main function of RANTES is mediated by CCR5, CCR1, CCR3 and other receptors. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways. Polymorphisms in the gene encoding RANTES are implicated in artherosclerosis, multiple sclerosis, HIV infection, diabetes, inflammatory diseases of the lung, renal disease and systemic lupus erythematosus. In addition, RANTES is a potential prognostic factor to track the progression of stage II breast cancer
Anti-RANTES antibody specifically recognizes human RANTES. The antibody shows ~40% cross-reactivity with mouse RANTES and canine RANTES, ~20% cross-reactivity with cotton rat RANTES, and ~1% cross-reactivity with feline RANTES.
Anti-RANTES antibody specifically recognizes human RANTES. The antibody shows ~40% cross-reactivity with mouse RANTES and canine RANTES, ~20% cross-reactivity with cotton rat RANTES, and ~1% cross-reactivity with feline RANTES.
Specificità
Based on ELISA, the antibody shows ~40% cross-reactivity with recombinant mouse RANTES, ~20% cross-reactivity with recombinant cotton rat RANTES, and ~1% cross-reactivity with recombinant feline RANTES.
Immunogeno
recombinant human RANTES expressed in E. coli.
Applicazioni
Anti-RANTES antibody may be used for immunoblotting at a working concentration of 0.1 μg/ml. For immunohistochemistry and immunofluorescence, a working concentration of 5-15 μg/ml may be used. The antibody is suitable for neutralization reactions (ND50 is 0.1-0.4 μg/ml).
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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F Villalta et al.
Infection and immunity, 66(10), 4690-4695 (1998-09-24)
This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1alpha, and MIP-1beta on human macrophage function, which is the induction of nitric oxide (NO)-mediated trypanocidal activity. In a previous report, we showed that RANTES, MIP-1alpha and MIP-1beta
Alan M Krensky et al.
Nature clinical practice. Nephrology, 3(3), 164-170 (2007-02-27)
Chemokines (chemoattractant cytokines) are fundamental regulators of immune cell movement from the bloodstream into tissues. Regulating expression of chemokines might, therefore, alleviate inflammation in autoimmune diseases and transplant rejection, or augment immune responses in cancer and immunodeficiency. RANTES (regulated upon
Caitlin M Guenther et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(3), 611-622 (2019-02-18)
Adeno-associated virus (AAV) has emerged as a promising gene delivery vector because of its non-pathogenicity, simple structure and genome, and low immunogenicity compared to other viruses. However, its adoption as a safe and effective delivery vector for certain diseases relies
Neora Yaal-Hahoshen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(15), 4474-4480 (2006-08-11)
The aim of this study was to determine the prognostic value of the chemokine CCL5, considered as a promalignancy factor in breast cancer, in predicting breast cancer progression and to evaluate its ability to strengthen the prognostic significance of other
V Appay et al.
Trends in immunology, 22(2), 83-87 (2001-04-05)
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some
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