M1787

Manganese(II) chloride solution

BioReagent, for molecular biology, storage temp.:room temp

• Sinonimo/i: Manganese chlroide, Manganese(II) chloride, MnCl₂
• Formula condensata: MnCl₂
• Numero CAS: 7773-01-5
• Peso molecolare: 125.84
• Numero MDL: MFCD00011114
• Codice UNSPSC: 12352302
• ID PubChem: 24896693
• NACRES: NA.52

Proprietà

• Grado: for molecular biology
• Livello qualitativo: 200
• Sterilità: 0.2 μm filtered
• Nome Commerciale: BioReagent
• Forma fisica: liquid
• Concentrazione: 1.00 M±0.01 M
• Cationi in tracce: heavy metals (as Pb): ≤5 ppm
• Attività estranea: DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected
• Temperatura di conservazione: room temp
• Stringa SMILE: Cl[Mn]Cl
• InChI: 1S/2ClH.Mn/h2*1H;/q;;+2/p-2; GLFNIEUTAYBVOC-UHFFFAOYSA-L

Descrizione

Descrizione generale

Manganese (II) chloride (MnCl₂) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl₂ has been used in reverse transcription reaction mix to enhance the template-switching efficiency.

MnCl₂ solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn₂⁺ can be substituted for Mg₂⁺ as a divalent metal ion to facilitate DNase I activity in presence of Ca₂⁺.

Applicazioni

Manganese (II) chloride solution has been used:

• in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
• in high ionic strength reaction mixture to determine RNA polymerase I and II activity
• in reverse transcription reaction mix as a source of Mn₂⁺ ions

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H318,H373
• Consigli di prudenza: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Classi di pericolo: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2
• Organi bersaglio: Brain
• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)