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Merck
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B8061

Sigma-Aldrich

N-Butyl-N-(4-hydroxybutyl)nitrosamine

ISOPAC®, ≥90% (GC)

Sinonimo/i:

BBN, N-Butyl-N-butan-4-ol-nitrosamine, N-Butyl-N-nitroso-4-aminobutanol

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About This Item

Formula empirica (notazione di Hill):
C8H18N2O2
Numero CAS:
3817-11-6
Peso molecolare:
174.24
Codice UNSPSC:
12352116
NACRES:
NA.25

Saggio

≥90% (GC)

Forma fisica

liquid

Temperatura di conservazione

2-8°C

InChI

1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3
DIKPQFXYECAYPC-UHFFFAOYSA-N

Applicazioni

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a carcinogen, is used to induce histiologically relevant aggressive urinary bladder cancer in animal models.

Azioni biochim/fisiol

Carcinogen used to induce urinary bladder cancer in animal models. The result of exposure is histologically comparable to human urinary bladder tumorigenesis. Used in chemopreventative studies.

Confezionamento

Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.

Avvertenza

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Ricostituzione

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Note legali

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H350

Classi di pericolo

Acute Tox. 4 Oral - Carc. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

296.6 °F

Punto d’infiammabilità (°C)

147 °C

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

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Tamoxifene

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Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given
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Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange
Koji Nishizawa et al.
International journal of cancer, 127(5), 1180-1187 (2009-12-30)
We previously reported that the expression of CXC chemokine receptor-4 (CXCR4) was upregulated in invasive bladder cancers and that the small peptide T140 was a highly sensitive antagonist for CXCR4. In this study, we identified that CXCR4 expression was induced
Xiao-Li Xie et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 3934-3940 (2012-08-15)
In the present study, effects of L-leucine and L-isoleucine on rat bladder carcinogenesis were investigated using AIN-93G and MF basal diet. In Experiment 1, N-butyl-N-(4-hydroxybutyl)-nitrosamine was used as an initiator of bladder carcinogenesis. In the AIN-93G diet groups, a significantly
Zhiming He et al.
Mutation research, 742(1-2), 92-95 (2011-12-14)
Bladder cancer is one of the few cancers that have been linked to carcinogens in the environment and tobacco smoke. Of the carcinogens tested in mouse chemical carcinogenesis models, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is one that reproducibly causes high-grade, invasive cancers in
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