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213942

Sigma-Aldrich

3-Methylcholanthrene

98%

Sinonimo/i:

20-Methylcholanthrene, Methylcholanthrene

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About This Item

Formula empirica (notazione di Hill):
C21H16
Numero CAS:
56-49-5
Peso molecolare:
268.35
Beilstein:
1913890
Numero CE:
200-276-4
Numero MDL:
MFCD00003704
Codice UNSPSC:
12352005
ID PubChem:
57647926
NACRES:
NA.25

Saggio

98%

Forma fisica

solid

P. eboll.

280 °C/80 mmHg (lit.)

Punto di fusione

178-180 °C (lit.)

Stringa SMILE

Cc1ccc2cc3c(ccc4ccccc34)c5CCc1c25

InChI

1S/C21H16/c1-13-6-7-15-12-20-17-5-3-2-4-14(17)8-9-18(20)19-11-10-16(13)21(15)19/h2-9,12H,10-11H2,1H3
PPQNQXQZIWHJRB-UHFFFAOYSA-N

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Applicazioni

3-Methylcholanthrene has been used to assess its tumor initiation activity by Bhas 42 cell transformation assay. It has also been used to induce the activity of cytochrome P450.

Azioni biochim/fisiol

3-Methylcholanthrene is a carcinogen used to induce transformation of cultured cells. It is also used to induce fibrosarcomas and skin carcinomas in laboratory animals. 3-methylcholanthrene is a potent aryl hydrocarbon receptor agonist.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H350,H413

Consigli di prudenza

P201 - P273 - P308 + P313

Classi di pericolo

Aquatic Chronic 4 - Carc. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

73861

N-Nitrosodiethylamine

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Sigma-Aldrich

M1390

3,3′-Methylene-bis(4-hydroxycoumarin)

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Sigma-Aldrich

N3385

N-Nitroso-N-ethylurea

Nadine Y Crowe et al.
The Journal of experimental medicine, 196(1), 119-127 (2002-07-03)
Natural killer (NK) T cells initiate potent antitumor responses when stimulated by exogenous factors such as interleukin (IL)-12 or alpha-galactosylceramide (alpha-GalCer), however, it is not clear whether this reflects a physiological role for these cells in tumor immunity. Through adoptive
A high-throughput Bhas 42 cell transformation assay for the determination of the carcinogenicity of three herbal extracts
Pu J, et al.
Fundamental Toxicological Sciences, 3(4), 157-166 (2016)
Simple machine perfusion significantly enhances hepatocyte yields of ischemic and fresh rat livers
Izamis ML, et al.
Cell medicine, 4(3), 109-123 (2013)
Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases
Yi T, et al.
BioMed Research International, 1-11 (2018)
Elin Swedenborg et al.
Molecular and cellular endocrinology, 362(1-2), 39-47 (2012-05-29)
The two estrogen receptor isoforms ERα and ERβ mediate biological effects of estrogens, but are also targets for endocrine disruptive chemicals (EDCs), compounds that interfere with hormonal signaling. 3-Methylcholanthrene (3-MC) and dioxin (TCDD) are EDCs and prototypical aryl hydrocarbon receptor
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