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T2695

Supelco

Tetrandrine

analytical standard, for drug analysis

Sinonimo/i:

(1β)-6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman

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About This Item

Formula empirica (notazione di Hill):
C38H42N2O6
Numero CAS:
Peso molecolare:
622.75
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

analytical standard, for drug analysis

Livello qualitativo

Saggio

≥90%

Forma fisica

solid

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Formato

neat

Stringa SMILE

COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34

InChI

1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
WVTKBKWTSCPRNU-KYJUHHDHSA-N

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Descrizione generale

Tetrandrine (TET) is classified under the bisbenzylisoquinoline alkaloid family of compounds extracted from Stephania tetrandra S. Moore.

Applicazioni

Analgesic, antipyretic.
TET may be used as an analytical reference standard for the determination of TET in:
  • Blood samples by online multidimensional solid phase extraction liquid chromatography coupled to tandem mass spectrometry (MD-SPE-LC-MS/MS) equipped with electrospray ionization (ESI) source and multiple reaction monitoring (MRM) detection.
  • Rat plasma by ultra-high performance liquid chromatography (UHPLC) combined with MS/MS with MRM detection.
  • Qi-Fang-Xi-Bi-Granules used in Chinese medicine by reversed phase HPLC equipped with ultraviolet (UV) detector.
  • Fangji Huangqi Tang Chinese medicine by UHPLC coupled to triple quadrupole mass spectrometry (QqQ-MS) with MRM detection.

It may be used as an internal standard for the determination of hernandezine in:
  • Rat plasma and tissues by UHPLC-MS/MS with MRM detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Skull and crossbones

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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C Y Kwan et al.
Life sciences, 68(7), 841-847 (2001-02-24)
The effects of tetrandrine (TET), a Ca2+ antagonist of bis-benzylisoquinoline alkaloid origin, on cultured single bovine pulmonary artery endothelial cells were examined using fluorescence ratio imaging and whole-cell attached patch-clamp techniques. Thapsigargin (TSG, 100 nM), a selective endoplasmic reticulum Ca2+-ATPase
Development and validation of an UHPLC-QqQ-MS technique for simultaneous determination of ten bioactive components in Fangji Huangqi Tang.
Wang X, et al.
Journal of Analytical Methods in Chemistry, 2016(8), 1328-1332 (2016)
Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study.
Song Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 141(8), 132-139 (2017)
Ultra high performance liquid chromatography with tandem mass spectrometry method for the determination of tetrandrine and fangchinoline in rat plasma after oral administration of Fangji Huangqi Tang and Stephania tetrandra S. Moore extracts.
Wang X, et al.
Journal of Separation Science, 38(8), 1286-1293 (2015)
Development and validation of an on-line multidimensional SPE-LC-MS/MS method for the quantitation of Tetrandrine in blood samples.
Caglar S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 988, 25-32 (2015)

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