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Halofuginone hydrobromide

VETRANAL®, analytical standard

Sinonimo/i:

trans-(±)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone monohydrobromide

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About This Item

Formula empirica (notazione di Hill):
C16H17BrClN3O3 · HBr
Numero CAS:
64924-67-0
Peso molecolare:
495.59
Numero MDL:
MFCD23843776
Codice UNSPSC:
41116107
ID PubChem:
329754239
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Nome Commerciale

VETRANAL®

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

Br.O[C@@H]1CCCN[C@H]1CC(=O)CN2C=Nc3cc(Br)c(Cl)cc3C2=O

InChI

1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/m0./s1
SJUWEPZBTXEUMU-LDXVYITESA-N

Categorie correlate

Descrizione generale

Halofuginone hydrobromide is a synthetic alkaloid derivative of febrifugine, used widely against coccidiosis in the poultry sector. It′s a specific collagen Type I inhibitor that antagonizes or inhibits the development of new blood vessels and hence can prevent intimal hyperplasia at a vascular anastomosis.

Applicazioni

The analytical standard can be used as follows:
  • Multi-residue analysis of 11 coccidiostats in 60 feed samples by reversed phase-high performance liquid chromatography (RP-HPLC) combined with tandem mass spectrometry (MS/MS)
  • Simultaneous determination of 15 allowed and banned coccidiostats in animal feed samples by liquid chromatography-tandem mass spectrometry method (LC-MS/MS)
  • UHPLC-MS/MS method-based detection and measurement of 26 anticoccidials in surface and groundwater samples following their solid phase extraction (SPE)
  • Analysis of 48 anti-microbial compounds in pig feed samples using LC combined with high-resolution mass spectrometry (HRMS)(4)Development of an LC-MS/MS method to determine 20 coccidiostats in different animal muscle samples

Altre note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Note legali

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Skull and crossbonesEnvironment
GHS06,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330,H315,H319,H410

Classi di pericolo

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Choose from one of the most recent versions:

Certificati d'analisi (COA)

Lot/Batch Number
BCCL4906
BCCH6215
BCCF5060
BCCC8473
BCBW0721

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Halofuginone, a specific collagen type I inhibitor, reduces anastomotic intimal hyperplasia.
Choi, Eric T., et al.
Archives of Surgery (Chicago, Ill. : 1960), 130 (3), 257-261 (1995)
Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology
Zhang, De-Fu, et al.
Parasitology Research, 111 (2), 695-701 (2012)
Gili Wellner et al.
Histology and histopathology, 34(7), 791-801 (2019-01-11)
In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to
Sumbul Afroz et al.
Frontiers in immunology, 11, 1831-1831 (2020-09-10)
Nutrient sensor GCN2 plays a crucial role in the maintenance of cellular homeostasis during the condition of amino acid deprivation. Dysfunction in the GCN2 signaling underlies several chronic metabolic diseases. Recent studies highlight the anti-viral potential of GCN2 against RNA
Kianna Y Elahi-Gedwillo et al.
Cancer research, 79(2), 372-386 (2018-11-08)
Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest forms of cancer, in part, because it is largely refractory to current therapies. The failure of most standard therapies in PDA, as well as promising immune therapies, may be largely ascribed
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