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MAB3070

Sigma-Aldrich

Anti-Granzyme B Antibody, clone GrB-7

culture supernatant, clone GrB-7, Chemicon®

Sinonimo/i:

Anti-Anti-C11, Anti-Anti-CCPI, Anti-Anti-CGL-1, Anti-Anti-CGL1, Anti-Anti-CSP-B, Anti-Anti-CSPB, Anti-Anti-CTLA1, Anti-Anti-CTSGL1, Anti-Anti-HLP, Anti-Anti-SECT

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250 μL
478,00 €

478,00 €


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Cambia visualizzazione
250 μL
478,00 €

About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

478,00 €


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Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

GrB-7, monoclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Chemicon®

tecniche

immunohistochemistry: suitable (paraffin)
western blot: suitable

Isotipo

IgG2a

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GZMB(3002)

Specificità

Monoclonal antibody recognizes the 33 kDa granzyme B.

Reacts specifically with human serine protease granzyme B. Does not cross-react with human granzyme A. Granzyme B localizes in cytoplasmic granules and can be used as a marker for NK cells and activated cytotoxic T-cells.

Applicazioni

Detect Granzyme B using this Anti-Granzyme B Antibody, clone GrB-7 validated for use in WB, IH(P).
Immunoblotting

Immunohistochemistry of granzyme B-expressing lymphocytes in sublimate sections and formalin-fixed paraffin-embedded tissues (1:20 dilution). Does not react with other cell types. Cannot be used on frozen sections.

Note on the use of MAB3070 on paraffin sections:

Tissue slides should be pretreated with an antigen retrieval method, such as treatment with 0.1M sodium citrate for 10 min at 100°C. A working dilution of 1:20 is advised, but optimal working dilutions must be determined by end user.
Research Category
Apoptosis & Cancer

Metabolism
Research Sub Category
Apoptosis - Additional

Enzymes & Biochemistry

Stato fisico

Liquid

Stoccaggio e stabilità

Maintain at -20°C for up to 12 months.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2


Certificati d'analisi (COA)

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Journal of neuroinflammation, 7, 76-76 (2010-11-11)
The contribution of inflammation to neurodegenerative diseases is increasingly recognized, but the role of inflammation in sporadic amyotrophic lateral sclerosis (sALS) is not well understood and no animal model is available. We used enzyme-linked immunosorbent assays (ELISAs) to measure the
Jenny Bulgarelli et al.
Frontiers in immunology, 10, 2353-2353 (2019-10-28)
Dendritic cell (DC)-based vaccination effectively induces anti-tumor immunity, although in the majority of cases this does not translate into a durable clinical response. However, DC vaccination is characterized by a robust safety profile, making this treatment a potential candidate for
Shintaro Yokoyama et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(18), 4727-4734 (2016-05-12)
The immune checkpoint of the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is believed to play an important role in evasion of host antitumor immune surveillance in various malignancies; however, little is known about its role in thymic carcinoma.
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The Journal of biological chemistry, 293(51), 19600-19612 (2018-10-20)
Several clinical immunotherapy trials with cytokine-induced killer (CIK) cells have been reported. However, molecular evidence of cell expansion, acquisition of tumor cytotoxicity, and safety of CIK cells is required before putting them to clinical use. Here, we performed dynamic transcriptomic
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