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596200

Thioflavin T

Name: Thioflavin T
Brand: MM
Price: 132 EUR
Availability: InStock

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils.

Sinonimo/i:

Thioflavin T, ThT, Thioflavine T, Basic Yellow 1

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Taglio della confezione	SKU	Disponibilità	Prezzo
500 mg		Disponibile per la spedizione OGGIdaMerck S.p.A	132,00 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₇H₁₉ClN₂S

Numero CAS:

2390-54-7

Peso molecolare:

318.86

UNSPSC Code:

12171500

NACRES:

NA.25

MDL number:

MFCD00011944

132,00 €

Disponibile per la spedizione OGGIDettagli

Servizio Tecnico

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Proprietà

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

water: 5 mg/mL

fluorescence

λ_ex ~385 nm (free), λ_ex ~437 nm, λ_em ~445 nm (free), λ_em ~485 nm

shipped in

ambient

storage temp.

15-25°C

SMILES string

S1c2c(ccc(c2)C)N(C1=C3C=CC(=[N+](C)C)C=C3)C.[Cl-]

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

Descrizione

General description

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Useful in monitoring stacked β sheet aggregates. Associates with aggregated fibrils of synthetic β/A4-derived peptides β(1-28) and β(1-40), resulting in a shift in the excitation maximum and an enhanced emission. Excitation max.: ~385 nm (free); ~437 nm (bound); emission max.: ~445 nm (free); ~485 nm (bound).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Exhibits enhanced fluorescence upon binding to amyloid fibrils

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tjernberg, L.O., et al. 1999. J. Biol. Chem.274, 12619.
Naiki, H. and Nakakuki, K. 1996. Lab. Invest.74, 374.
LeVine, H. 1993. Protein Sci.2, 404.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Questo articolo	T3516	T1892	8.40072
Sigma-Aldrich 596200 Thioflavin T	Sigma-Aldrich T3516 Thioflavin T	Sigma-Aldrich T1892 Thioflavine S	Sigma-Aldrich 8.40072 Thioflavine T (C.I.No.49005)
fluorescence λ_ex ~385 nm (free), λ_em ~445 nm (free), λ_ex ~437 nm, λ_em ~485 nm	fluorescence -	fluorescence -	fluorescence -
color yellow	color -	color light beige to dark beige, to Dark Brown	color -
form solid	form powder	form powder	form powder
solubility water: 5 mg/mL	solubility methanol: 1 mg/mL	solubility ethanol: water (1:1): 1 mg/mL	solubility -
shipped in ambient	shipped in -	shipped in -	shipped in -
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200

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pictograms

GHS06,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H410

pcodes

P261 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c