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Documenti

880343P

Avanti

PChemsPC

Avanti Research™ - A Croda Brand 880343P, powder

Sinonimo/i:

1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine

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About This Item

Formula empirica (notazione di Hill):
C55H98NO10P
Numero CAS:
155401-40-4
Peso molecolare:
964.34
Codice UNSPSC:
51191904
NACRES:
NA.25

Forma fisica

powder

Confezionamento

pkg of 1 × 25 mg (880343P-25mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 880343P

Tipo di lipide

phospholipids
cardiolipins

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

O=P([O-])(OCC[N+](C)(C)C)OC[C@H](OC(CCC(OC1CC[C@]2(C)C(C1)=CCC3C2CC[C@]4(C)C3CC[C@H]4[C@@H](C)CCCC(C)C)=O)=O)COC(CCCCCCCCCCCCCCC)=O

Applicazioni

PChemsPC or 1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine might be used to study its pharmacokinetics and biodistribution patterns in comparison with phospholipid-cholesterol liposomes. It might also be used as a component in the monolayer to study its characterization at the air/water interface.

Azioni biochim/fisiol

PChemsPC or 1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine is a sterol-phospholipid hybrid. Cholesterol incorporation with phospholipids reduces the permeability of the lipid bilayer, organizes phospholipid chains and avoids the phospholipid phase transition. This improves the stability of the vesicles.

Confezionamento

5 mL Amber Glass Screw Cap Vial (880343P-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

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Michał Flasiński et al.
Langmuir : the ACS journal of surfaces and colloids, 32(16), 4095-4102 (2016-04-06)
The two synthetic sterol-phospholipid hybrids DCholPC and PCholPC were investigated in monolayers at the air/water interface. Study was based on π-A isotherm analysis complemented with application of grazing incidence X-ray diffraction. It was found that both compounds are capable of
Aditya G Kohli et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 86-93 (2013-12-26)
We introduce a method for tracking the rate and extent of delivery of liposome contents in vivo based on encapsulation of 4-methylumbelliferyl phosphate (MU-P), a profluorophore of 4-methylumbelliferone (MU). MU-P is rapidly dephosphorylated by endogenous phosphatases in vivo to form
Maryam Iman et al.
International journal of pharmaceutics, 408(1-2), 163-172 (2011-02-01)
1,2-Di-stigma-steryl-hemi-succinoyl-sn-glycero-3-phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Since amphotericin B (AmB) interacts with sterols, we postulated that DSHemsPC could be used in
F Foglia et al.
Langmuir : the ACS journal of surfaces and colloids, 27(13), 8275-8281 (2011-06-04)
Langmuir isotherm, neutron reflectivity, and small angle neutron scattering studies have been conducted to characterize the monolayers and vesicular bilayers formed by a novel chimeric phospholipid, ChemPPC, that incorporates a cholesteryl moeity and a C-16 aliphatic chain, each covalently linked
Zhaohua Huang et al.
Journal of the American Chemical Society, 130(46), 15702-15712 (2008-10-28)
We synthesized a family of sterol-modified glycerophospholipids (SML) in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative position contains an aliphatic chain. The SML were used to explore how anchoring cholesterol to a phospholipid
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