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Merck
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Documenti

88310

Sigma-Aldrich

Theophylline-7-acetic acid

≥99.0% (T)

Sinonimo/i:

1,3-Dimethylxanthine-7-acetic acid

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About This Item

Formula empirica (notazione di Hill):
C9H10N4O4
Numero CAS:
652-37-9
Peso molecolare:
238.20
Beilstein:
279221
Numero CE:
211-490-2
Numero MDL:
MFCD00022832
Codice UNSPSC:
12352005
ID PubChem:
57653298
NACRES:
NA.22

Saggio

≥99.0% (T)

Forma fisica

powder

Stringa SMILE

CN1C(=O)N(C)c2ncn(CC(O)=O)c2C1=O

InChI

1S/C9H10N4O4/c1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h4H,3H2,1-2H3,(H,14,15)
HCYFGRCYSCXKNQ-UHFFFAOYSA-N

Informazioni sul gene

human ... ADORA2B(136)

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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G Grosa et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 267-270 (1986-03-01)
The metabolic transformation of the bronchospasmolytic agent doxophylline (2-(7'-theophyllinemethyl)-1,3-dioxolane) was studied in vitro with phenobarbital-induced rat liver microsomal fraction containing the NADPH-generating system. Doxophylline was poorly metabolized as 95% of the recovered material was parent compound. The major metabolite resulted:
J G Ufkes et al.
Archives internationales de pharmacodynamie et de therapie, 253(2), 301-314 (1981-10-01)
A study has been made of the bronchospasmolytic actions of theophylline and some ot its N-7-substituted derivatives administered by i.v infusion in anaesthetized guinea pigs, in which experimental bronchial asthma was induced by i.v. administration of histamine, 5-hydroxytryptamine and bradykinin.
C Ferretti et al.
International journal of tissue reactions, 14(1), 31-36 (1992-01-01)
It is assumed that theophylline (THEO) and its xanthinic derivatives inhibit lung phosphodiesterase (PDE) and block adenosine receptors in the induction of bronchodilatation. Since the theophyllinic compound ambroxol-theophylline-7-acetic acid (ATA) has been shown in vivo to be a sound bronchodilator
G Dănilă et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 94(3-4), 581-586 (1990-10-01)
Some esters of 7-theophyllinylacetic acid were synthetized, characterized physicochemically and tested for their anti-inflammatory properties. As compared to indomethacin, reference anti-inflammatory drug, all synthetized compounds were less toxic. The anti-inflammatory properties are influenced by the nature of the ester group
K Primbs
Clinical therapeutics, 7(6), 733-736 (1985-01-01)
In an open study, 50 patients suffering from chronic obstructive pulmonary disease in an acute infectious phase were treated with ambroxol theophyllinacetate. The drug was given orally in a dosage of 100 mg BID for ten days. Viscosimetric data showed
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