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Merck
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Documenti

47300

Sigma-Aldrich

o-Fluoro-DL-phenylalanine

≥98%

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About This Item

Formula condensata:
FC6H4CH2CH(NH2)COOH
Numero CAS:
2629-55-2
Peso molecolare:
183.18
Beilstein:
3201186
Numero CE:
220-105-7
Numero MDL:
MFCD00004271
Codice UNSPSC:
12352200
ID PubChem:
57650911
NACRES:
NA.22

Saggio

≥95% (NT)
≥98% (HPLC)
≥98%

Forma fisica

powder

Impiego in reazioni chimiche

reaction type: solution phase peptide synthesis

Colore

white to faint brown

Punto di fusione

243-246 °C (lit.)

applicazioni

cell analysis
peptide synthesis

Stringa SMILE

NC(Cc1ccccc1F)C(O)=O

InChI

1S/C9H10FNO2/c10-7-4-2-1-3-6(7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
NYCRCTMDYITATC-UHFFFAOYSA-N

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Applicazioni

Reactant involved in:
  • Studying mechanism of P 450-mediated oxidation and rearrangement
  • Conversion of racemic α-arylalanines to (R)-β-arylalanines
  • Ribosomal translation of unnatural peptides
  • Synthesis of diisopropylpyridine acetamides for use as Kv1.5 potassium channel antagonists
  • Enantioselective hydrolysis of esters for resolution of nonprotein amino acids

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Kensuke Okuda et al.
Biochemistry, 44(17), 6675-6684 (2005-04-27)
The ribosome-catalyzed peptidyl transferase reaction displays a complex pH profile resulting from two functional groups whose deprotonation is important for the reaction, one within the A-site substrate and a second unidentified group thought to reside in the rRNA peptidyl transferase
K Kubota et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 37(2), 320-325 (1996-02-01)
L-[methyl-11C]methionine (11C-Met) is a useful tracer for tumor imaging with PET. The drawbacks include a short half-life and high physiological accumulation in abdominal organs. To overcome these shortfalls, the feasible use of [18F]fluorophenylalanine (18F-Phe), which shares the same amino acid
Johnny Castillo Meleán et al.
Organic & biomolecular chemistry, 9(3), 765-769 (2010-11-23)
2-[(18)F]Fluoro-L-phenylalanine and 2-[(18)F]fluoro-L-tyrosine have been developed as promising radiopharmaceuticals for molecular imaging using positron emission tomography (PET). However, the lack of a convenient radiosynthetic pathway has limited their practical use. In this work a new three-step nucleophilic synthesis of these
H Ito et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 36(7), 1232-1237 (1995-07-01)
Neutral amino acids (NAAs) are transported from the blood to the brain using the same carrier system in a competitive fashion. The purpose of this study is to establish a method for evaluating neutral amino acid transport at the blood-brain
J Hatazawa et al.
Annals of nuclear medicine, 8(3), 213-217 (1994-08-01)
We studied the brain uptake of amino acid in a patient with acute cerebral infarction with L-[2-(F-18)]fluorophenylalanine and positron emission tomography. The increased accumulation of the ligand was specifically found in the peri-infarct area where oxygen metabolism was still maintained
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