416274
N-Phenylphthalimide
98%
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About This Item
Formula empirica (notazione di Hill):
C14H9NO2
Numero CAS:
Peso molecolare:
223.23
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
Prodotti consigliati
Saggio
98%
Forma fisica
powder
Punto di fusione
204-207 °C (lit.)
Stringa SMILE
O=C1N(c2ccccc2)C(=O)c3ccccc13
InChI
1S/C14H9NO2/c16-13-11-8-4-5-9-12(11)14(17)15(13)10-6-2-1-3-7-10/h1-9H
MFUPLJQNEXUUDW-UHFFFAOYSA-N
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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R Shimazawa et al.
Bioorganic & medicinal chemistry letters, 9(4), 559-562 (1999-03-31)
A novel series of nonpeptide small-molecular dipeptidyl peptidase IV (DPP-IV) inhibitors with an N-phenylphthalimide skeleton has been developed. Some of the compounds, including 4-amino-(2,6-dimethylphenyl)phthalimides (7), 4- and 5-hydroxy-(2,6-diethylphenyl)phthalimide (11 and 14), 4-hydroxy-(2,6-diisopropylphenyl)phthalimide (12), and thiocarbonyl analogs of (2,6-diisopropylphenyl)phthalimide and their
Hiroko Sano et al.
Chemical & pharmaceutical bulletin, 52(8), 1021-1022 (2004-08-12)
Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.
Masashi Tetsuhashi et al.
Bioorganic & medicinal chemistry, 18(14), 5323-5338 (2010-06-22)
A novel series of tryptase inhibitors with a N-phenylphthalimide skeleton structurally derived from thalidomide (1) has been developed. Structure-activity relationship studies led to a potent and selective tryptase inhibitor, 2-(4-cyanophenyl)isoindole-1,3-dione-5-yl 3-(2-aminopyridin-5-yl)propanoate (7), with the IC50 value of 78 nM.
The oxidative degradation of imide polymers. I: Ozonolysis of a model compound, N-phenylphthalimide.
Barman S, et al.
Polym. Eng. Sci., 34(4), 279-284 (1994)
Y Shibata et al.
Chemical & pharmaceutical bulletin, 44(1), 156-162 (1996-01-01)
Phenylphthalimides (2-phenyl-1H-isoindole-1,3-diones) were prepared and their effects on tumor necrosis factor alpha (TNF-alpha) production by human leukemia cell line HL-60 stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined. An analysis of the structure-activity relationships of the phenylphthalimides indicated that potent enhancing activity
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