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137111

Sigma-Aldrich

Ethoxyacetic acid

98%

Sinonimo/i:

O-Ethylglycolic acid

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About This Item

Formula condensata:
C2H5OCH2COOH
Numero CAS:
627-03-2
Peso molecolare:
104.10
Beilstein:
1743037
Numero CE:
210-978-2
Numero MDL:
MFCD00004310
Codice UNSPSC:
12352100
ID PubChem:
24848312
NACRES:
NA.22

Saggio

98%

Indice di rifrazione

n20/D 1.419 (lit.)

P. eboll.

97-100 °C/11 mmHg (lit.)

Densità

1.102 g/mL at 25 °C (lit.)

Stringa SMILE

CCOCC(O)=O

InChI

1S/C4H8O3/c1-2-7-3-4(5)6/h2-3H2,1H3,(H,5,6)
YZGQDNOIGFBYKF-UHFFFAOYSA-N

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Descrizione generale

Ethoxyacetic acid is biomarker of exposure to widely used industrial chemicals such as alkyl-substituted ethylene glycols and other aliphatic ethers.

Applicazioni

Ethoxyacetic acid is metabolite of glycol ether alkoxy acid and was used to evaluate its toxicity in embryonic stem cell test in mouse. It was used in zebrafish embryotoxicity test to study chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis in ovo.

Azioni biochim/fisiol

Ethoxyacetic acid induces testicular toxicity in rats in vivo .

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314

Classi di pericolo

Eye Dam. 1 - Skin Corr. 1B

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

206.6 °F - closed cup

Punto d’infiammabilità (°C)

97 °C - closed cup

Dispositivi di protezione individuale

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

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D Groeseneken et al.
International archives of occupational and environmental health, 61(4), 249-254 (1989-01-01)
A sensitive and specific method for the determination in urine of alkoxyacetic acids, the metabolites of ethylene glycol monoalkyl ethers, was developed by combining the advantages of two previously described methods. The acids were determined gas chromatographically as their pentafluorobenzylesters.
J C Hoflack et al.
Mutation research, 341(4), 281-287 (1995-02-01)
Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenicity with the Ames test. The Salmonella typhimurium his- tester strains TA 97a, TA 98, TA 100 and TA 102 were used with and without rat S9
L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(12), 1237-1244 (1998-02-14)
1. The elimination of 2-methoxyethanol (2-ME) and its toxic metabolite methoxyacetic acid (MAA) was studied in the male and female rat. We also studied the elimination of ethoxyacetic acid (EAA), the toxic metabolite formed by 2-ethoxyethanol (2-EE). 2. The rate
Esther de Jong et al.
Toxicological sciences : an official journal of the Society of Toxicology, 110(1), 117-124 (2009-04-30)
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within
T S Shih et al.
Occupational and environmental medicine, 56(7), 460-467 (1999-09-03)
To simplify the current preparation of samples, and to improve the specificity and reliability of the conventional analytical methods to measure urinary alkoxyacetic acids. Samples containing alkoxyacetic acids including methoxy, ethoxy, and butoxyacetic acids (MAA, EAA, and BAA) were acidified
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