- Allosteric modulation of nicotinic and GABA
Allosteric modulation of nicotinic and GABA
Neuropharmacology (2017-08-27)
Ryan F Yoshimura, Minhtam B Tran, Derk J Hogenkamp, Narielle L Ayala, Timothy Johnstone, Andrew J Dunnigan, Timothy K Gee, Kelvin W Gee
PMID28842344
ABSTRACT
Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for the core symptoms and the changes that underlie these behaviors are not fully understood. One hypothesis is an imbalance of the excitation (E)/inhibition (I) ratio with excessive E and diminished I occurring in specific neuronal circuits. Data suggests that both gamma-aminobutyric acid
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