- Rapid and efficient synthesis of 1,2,4-oxadiazoles utilizing polymer-supported reagents under microwave heating.
Rapid and efficient synthesis of 1,2,4-oxadiazoles utilizing polymer-supported reagents under microwave heating.
Organic letters (2005-02-25)
Ying Wang, Reagan L Miller, Daryl R Sauer, Stevan W Djuric
PMID15727476
ABSTRACT
1,2,4-Oxadiazoles can be rapidly and efficiently synthesized from a variety of readily available carboxylic acids and amidoximes using either method A or method B. The use of commercially available polymer-supported reagents combined with microwave heating resulted in high yields and purities of the product 1,2,4-oxadiazoles in an expeditious manner. [structure: see text]
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine, polymer-bound, 200-400 mesh, extent of labeling: 2.0-2.5 mmol/g loading, 1 % cross-linked