- A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin.
A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin.
Organic & biomolecular chemistry (2011-02-18)
Thomas J K Findley, David Sucunza, Laura C Miller, Matthew D Helm, Madeleine Helliwell, David T Davies, David J Procter
PMID21327225
ABSTRACT
The cis-hydrindane motif is found in a number of natural products that display important biological activity. A flexible, stereoselective approach to the framework has been developed that features highly diastereoselective, SmI(2)-mediated cyclisations. The strategy has been exploited in the first synthesis of the proposed structure of faurinone and an approach to the skeleton of the antibacterial natural product, pleuromutilin.
MATERIALS