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The Japanese toxicogenomics project: application of toxicogenomics.

Molecular nutrition & food research (2009-12-31)
Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani
ABSTRACT

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project.

MATERIALS
Product Number
Brand
Product Description

Supelco
Melting point standard 235-237°C, analytical standard
Supelco
Ibuprofen
Supelco
Cyclosporin A, VETRANAL®, analytical standard
Supelco
Nicotinic acid, analytical standard
Supelco
Ethanol solution, certified reference material, 2000 μg/mL in methanol
Supelco
Carbon tetrachloride, analytical standard
Sigma-Aldrich
Cyclosporin A, 97.0-101.5% (on dried basis)
Supelco
17α-Methyltestosterone, VETRANAL®, analytical standard
Supelco
Nitrofurantoin, VETRANAL®, analytical standard
Sigma-Aldrich
Carbon tetrachloride, anhydrous, ≥99.5%
Sigma-Aldrich
Bromobenzene, ReagentPlus®, 99%
Sigma-Aldrich
Mefenamic acid
Supelco
Caffeine solution, analytical standard, 1.0 mg/mL in methanol
Sigma-Aldrich
Tannic acid, ACS reagent
Sigma-Aldrich
2-Mercapto-1-methylimidazole, ≥99%
Sigma-Aldrich
Bromobenzene, ≥99.5% (GC)
Sigma-Aldrich
17α-Methyltestosterone, ≥97.0% (HPLC)
Sigma-Aldrich
Phenacetin, ≥98.0% (HPLC)
Sigma-Aldrich
Nicotinic acid, ≥99.5% (HPLC)
Sigma-Aldrich
(±)-Sulpiride
Sigma-Aldrich
Theophylline, anhydrous, ≥99%, powder
Sigma-Aldrich
Cyclosporin A, BioReagent, from Tolypocladium inflatum, for molecular biology, ≥95%
Sigma-Aldrich
Cyclosporin A, from Tolypocladium inflatum, ≥95% (HPLC), solid
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Rifampicin, suitable for plant cell culture, BioReagent, ≥95% (HPLC), powder or crystals
Sigma-Aldrich
Carbamazepine, powder
Sigma-Aldrich
Coumarin, ≥99% (HPLC)
Sigma-Aldrich
Nicotinic acid, ≥98%
Sigma-Aldrich
Indomethacin, meets USP testing specifications
Sigma-Aldrich
Nitrofurantoin, 98.0-102.0% (EP, UV)
Sigma-Aldrich
Indomethacin, 98.5-100.5% (in accordance with EP)