- Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Bioorganic & medicinal chemistry letters (2009-05-06)
Yusuke Sekiguchi, Tetsuko Nakaniwa, Takayoshi Kinoshita, Isao Nakanishi, Kazuo Kitaura, Akira Hirasawa, Gozoh Tsujimoto, Toshiji Tada
PMID19414254
ABSTRACT
We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.
MATERIALS
Product Number
Brand
Product Description
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity