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SRP4503

Sigma-Aldrich

FABP3 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):

Fatty acid-binding protein heart, H-FABP, Heart-type fatty acid-binding protein, M-FABP, Mammary-derived growth inhibitor, Muscle fatty acid-binding protein

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About This Item

MDL number:
MFCD00285932
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

lyophilized

mol wt

~19 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

P05413

UniProt accession no.

P05413

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FABP3(2170)

General description

Fatty acid binding proteins (FABPs) are intracellular proteins with a low molecular weight. They exhibit high affinity for small lipophilic ligands. FABP-3 is expressed in the skeletal muscle, heart, brain and brown adipose tissue. The gene encoding it is localized on human chromosome 1p35.

Biochem/physiol Actions

Studies suggest that fatty acid binding protein (FABPs) are involved in the uptake and metabolism of fatty acids, maintenance of cellular membrane fatty acids levels, intracellular trafficking, modulation of specific enzymes of lipid metabolic pathways, as well as in the modulation of cell growth and differentiation. FABPs have been associated with diabetes, obesity, atherosclerosis and brain function. FABP-3 has a role in glucose and lipid metabolism. It also modulates polysaturated fatty acid uptake and metabolism in neurons. The protein has been associated with schizophrenia, Down′s syndrome, Alzheimer′s disease and autism spectrum disorder.

Physical form

Sterile filtered and Lyophilized without additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Keren Kang et al.
Scandinavian journal of clinical and laboratory investigation, 75(8), 693-698 (2015-10-02)
To develop a rapid, sensitive and specific assay for quantification of serum heart-type fatty acid binding protein (H-FABP) based on immunofluorescence of specific monoclonal antibodies. We generated novel H-FABP-directed monoclonal antibodies by cloning of spleen cells of mice immunized with
Ondrej Libiger et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(12), 1976-1987 (2021-05-14)
Biomarkers that reflect pathologic processes affecting neuronal function during preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug development. A targeted, stable isotope, quantitative mass spectrometry-based investigation of longitudinal changes in concentrations of previously identified candidate
Accelerated expansion of group IID-like phospholipase A2 genes in Bos taurus.
Golik M
Genomics, 87(4), 527-533 (2006)
Tatsuya Kusudo et al.
FEBS letters, 589(18), 2382-2387 (2015-07-25)
Fatty acid-binding proteins (FABP) play a crucial role in intracellular fatty acid transportation and metabolism. In this study, we investigate the effects of the FABP3 Asp3Gly (D3G) polymorphism on protein structure and function. Although the mutation did not alter protein

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