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E5625

Sigma-Aldrich

α-Ergocryptine

Synonym(s):

12′-Hydroxy-2′-(1-methylethyl)-5′-α-(2-methylpropyl)ergotaman-3′,6′,18-trione

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About This Item

Empirical Formula (Hill Notation):
C32H41N5O5
CAS Number:
Molecular Weight:
575.70
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
ethanol: 3.2 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C

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Biochem/physiol Actions

Ergot alkaloid

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Repr. 2

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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D J Smith et al.
Journal of animal science, 80(6), 1616-1622 (2002-06-25)
Purified ergopeptine alkaloids are often used in studies related to tall fescue toxicosis without regard to epimerization that occurs when ergopeptines are solvated. The objectives of this study were to measure the rates of alpha-ergocryptine epimerization to alpha-ergocryptinine at room
J R Strickland et al.
American journal of veterinary research, 55(5), 716-721 (1994-05-01)
Cultured rat pituitary cells were studied to: determine the effects of ergovaline and loline on in vitro prolactin release; delineate the agonistic activity of these alkaloids at the D2 dopamine receptor, using 2 selective D2 dopamine receptor antagonists; and compare
J A Mattheij et al.
European journal of endocrinology, 132(1), 91-96 (1995-01-01)
The cause of formation of luteinized unruptured follicles (LUF) is unknown. Formation of LUF was studied after injection of a varying small dose of luteinizing hormone (LH) with or without subsequent injection of gonadotrophin-releasing hormone (GnRH); in addition, the effect
Thomas Haarmann et al.
Fungal genetics and biology : FG & B, 45(1), 35-44 (2007-06-15)
The ergot fungus Claviceps purpurea uses mainly the nonhomologous-end-joining (NHEJ) system for integration of exogenous DNA, leading to a low frequency of homologous integration (1-2%). To improve gene targeting efficiency we deleted the C. purpurea ku70 gene in two different
C Szántay et al.
Acta pharmaceutica Hungarica, 64(3), 105-108 (1994-05-01)
Two novel natural derivatives (2 and 3) of the ergot alkaloid alpha-ergokryptine (1), as well as their synthetically brominated analogues (5 and 6) were isolated and identified by NMR and MS methods. Compounds 2 and 5 contain what appears to

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