C2105

Z-Val-Ala-Asp fluoromethyl ketone

powder, ≥90% (TLC)

• Synonym(s): Z-VAD-FMK, Non-methylated
• Empirical Formula (Hill Notation): C₂₁H₂₈FN₃O₇
• CAS Number: 161401-82-7
• Molecular Weight: 453.46
• MDL number: MFCD03452883
• UNSPSC Code: 12352209
• PubChem Substance ID: 329774926
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥90% (TLC)
• form: powder
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CF
• InChI: 1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1
• InChI key: SUUHZYLYARUNIA-YEWWUXTCSA-N

Description

Amino Acid Sequence

Z-Val-Ala-Asp-OMe-FMK

Biochem/physiol Actions

Non-methylated competitive and irreversible inhibitor of caspase-1, as well as other caspases, which can be used directly with purified enzymes. It does not require esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(OMe) fluoromethyl ketone (Product Code V-116).

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves