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G2417

Supelco

Gabexate mesylate

analytical standard, for drug analysis

Synonym(s):

4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxyl]benzoic acid ethyl ester mesylate salt, FOY, Megacart

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About This Item

Empirical Formula (Hill Notation):
C16H23N3O4 · CH4O3S
CAS Number:
56974-61-9
Molecular Weight:
417.48
MDL number:
MFCD00210299
UNSPSC Code:
41116107
PubChem Substance ID:
329799903
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

200

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1

InChI

1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)

InChI key

DNTNDFLIKUKKOC-UHFFFAOYSA-N

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General description

Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases, which finds therapeutic applications in the treatment of disseminated intravascular coagulation and pancreatitis. It also plays the role of an anticoagulant in hemodialysis therapy.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
081K1764

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Kohei Uchimura et al.
American journal of physiology. Renal physiology, 303(7), F939-F943 (2012-07-27)
Aldosterone plays an important role in the regulation of blood pressure by modulating the activity of the epithelial sodium channel (ENaC) that consists of α-, β-, and γ-subunits. Aldosterone induces a molecular weight shift of γENaC from 85 to 70
James A Reihill et al.
Biomolecules, 10(4) (2020-04-02)
Epithelial barrier dysfunction, characteristic of allergic airway disease may be, at least in part, due to the action of allergen-associated protease activities. Cockroach allergy is a major global health issue, with cockroaches containing considerable serine trypsin-like protease (TLP) activity. The
Hirofumi Noguchi et al.
Cell transplantation, 21(2-3), 509-516 (2012-07-17)
For islet transplantation, maintaining organ viability after pancreas procurement is critically important for optimal graft function and survival. We recently reported that islet yield was significantly higher in the modified ET-Kyoto (MK) solution, which includes a trypsin inhibitor (ulinastatin), compared
Dalya M Lateef et al.
Physiology & behavior, 105(3), 829-834 (2011-11-04)
We have shown that vagotomy (VGX) attenuates the reduction of meal size (MS) produced by cholecystokinin (CCK) -8 and -33 and that celiaco-mesenteric ganglionectomy (CMGX) attenuates the prolongation of the intermeal interval (IMI) produced by CCK-33. Here, we report the
Gabexate mesylate inhibition of serine proteases: Thermodynamic and computer?graphics analysis.
Menegatti E, et al.
Journal of Pharmaceutical Sciences, 75(12), 1171-1174 (1986)
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Articles

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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