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Merck

HDAC3

histone deacetylase 3

Synonyms:
HD3, RPD3, RPD3-2
Species:
Human HDAC3 (8841), Mouse Hdac3 (15183), Rat Hdac3 (84578), fruit fly Hdac3 (44446), Zebrafish hdac3 (393965), cow HDAC3 (404125), chicken HDAC3 (395506), sheep HDAC3 (101107092), domestic guinea pig Hdac3 (100718985), dog HDAC3 (478040) ...More
UniProtKB ID:
O15379, D3DQE1, O43268, Q9UEI5, Q9UEV0
Gene ID:
  • Human(8841) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
  • Mouse(15183) histone deacetylase 3
  • Rat(84578) histone deacetylase 3
  • fruit fly(44446) Histone deacetylase 3
  • Zebrafish(393965) histone deacetylase 3
  • cow(404125) histone deacetylase 3
  • chicken(395506) histone deacetylase 3
  • sheep(101107092) histone deacetylase 3
  • domestic guinea pig(100718985) histone deacetylase 3
  • dog(478040) histone deacetylase 3
  • domestic cat(101100941) histone deacetylase 3
  • naked mole-rat(101708680) histone deacetylase 3

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Antibodies

Product Number
Description
Species Reactivity
Application
WH0008841M2
Monoclonal Anti-HDAC3 antibody produced in mouse, clone 3E11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
SAB4503481
Anti-HDAC3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB1411573
Anti-HDAC3 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB4504189
Anti-phospho-HDAC3 (pSer424) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
ZRB1725
Anti-HDAC3 Antibody, clone 1H19 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey, mouse, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
SML0061
SAHA, ≥98% (HPLC),
Species
human
C0621
CI−994, ≥98% (HPLC), powder,
Species
human
SML1175
Romidepsin, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
SRP2072
HDAC3 human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EMU090241
MISSION® esiRNA, targeting mouse Hdac3,
Species
mouse
EHU035581
MISSION® esiRNA, targeting human HDAC3,
Species
human