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Merck

CYBB

cytochrome b-245, beta polypeptide

Synonyms:
AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX
Species:
Human CYBB (1536), Mouse Cybb (13058), Rat Cybb (66021), cow CYBB (281112), sheep CYBB (100036757), Domestic Rabbit CYBB (100008801), dog CYBB (491825), chicken CYBB (418581), Zebrafish cybb (393386)
UniProtKB ID:
P04839, A8K138, Q2PP16
Gene ID:
  • Human(1536) Summary: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
  • Mouse(13058) cytochrome b-245, beta polypeptide
  • Rat(66021) cytochrome b-245, beta polypeptide
  • cow(281112) cytochrome b-245, beta polypeptide
  • sheep(100036757) cytochrome b-245, beta polypeptide
  • Domestic Rabbit(100008801) cytochrome b-245 beta polypeptide
  • dog(491825) cytochrome b-245, beta polypeptide (chronic granulomatous disease)
  • chicken(418581) cytochrome b-245, beta polypeptide
  • Zebrafish(393386) cytochrome b-245, beta polypeptide (chronic granulomatous disease)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2501192
Anti-CYBB antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
ELISA
immunohistochemistry
western blot
07-024
Anti-gp91-phox Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
western blot
AV44276
Anti-CYBB antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rabbit, rat
Application
western blot
SAB5702937
Anti-NOX2/gp91phox Antibody, clone 2Y8W3, Rabbit Monoclonal, ,
Species Reactivity
human, mouse, rat
Application
western blot
MABS2193
Anti-gp91phox (NOX2) Antibody, ,
Species Reactivity
human
Application
flow cytometry
inhibition assay
western blot

esiRNA

Product Number
Description
Species
EHU010941
MISSION® esiRNA, targeting human CYBB,
Species
human