CTSC
cathepsin C
Synonyms:
CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS
Species:
Human CTSC (1075), Mouse Ctsc (13032), Rat Ctsc (25423), domestic guinea pig Ctsc (100714387), naked mole-rat Ctsc (101697606), dog CTSC (403458), domestic cat CTSC (101092140), sheep CTSC (101112686), Zebrafish ctsc (368704), chicken CTSC (419014)
UniProtKB ID:
Gene ID:
- Human(1075) Summary: The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(13032) cathepsin C
- Rat(25423) cathepsin C
- domestic guinea pig(100714387) cathepsin C
- naked mole-rat(101697606) cathepsin C
- dog(403458) cathepsin C
- domestic cat(101092140) cathepsin C
- sheep(101112686) cathepsin C
- Zebrafish(368704) cathepsin C
- chicken(419014) cathepsin C
- cow(352958) cathepsin C
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CTSC antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Dipeptidyl-peptidase 1 (heavy chain, Cleaved-Arg394) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-CTSC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Proteins
Product Number
Description
Species