COMT
catechol-O-methyltransferase
Synonyms:
Species:
Human COMT (1312), Mouse Comt (12846), Rat Comt (24267), cow COMT (618278), domestic guinea pig Comt (100730509), domestic cat COMT (101097022), naked mole-rat Comt (101717730), chicken COMT (416783), Horse COMT (100146509), fruit fly comt (47091)
UniProtKB ID:
Gene ID:
- Human(1312) Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
- Mouse(12846) catechol-O-methyltransferase
- Rat(24267) catechol-O-methyltransferase
- cow(618278) catechol-O-methyltransferase
- domestic guinea pig(100730509) catechol-O-methyltransferase
- domestic cat(101097022) catechol-O-methyltransferase
- naked mole-rat(101717730) catechol-O-methyltransferase
- chicken(416783) catechol-O-methyltransferase
- Horse(100146509) catechol-O-methyltransferase
- fruit fly(47091) comatose
- dog(445450) catechol-O-methyltransferase
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-COMT antibody produced in mouse, clone 1G4-1A1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-COMT Antibody, clone 9Y2A3, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-Catechol O-methyltransferase/COMT Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, horse, human, porcine, rhesus macaque
Application
immunohistochemistry
western blot
western blot
Anti-COMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
western blot
Anti-COMT antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
esiRNA
Product Number
Description
Species