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Key Documents

LO4200

Sigma-Aldrich

LOPAC®1280 - Small Scale

International Version

Synonym(s):

Library of Pharmacologically Active Compounds - small scale

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About This Item

EC Number:
200-664-3
UNSPSC Code:
12352200
NACRES:
NA.77

form

liquid

shipped in

dry ice

storage temp.

−20°C

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General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).

Application

Library of pharmacologically active compounds LOPAC®1280 - small scale has been used to screen for the suppressors of niclosamide- and nigericin-induced interleukin (IL-1β) release.

Features and Benefits

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apoptosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-Drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:
  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Product Number
  • Rack Position

Other Notes

For sale outside of the U.S. only. U.S. customers should refer to Product Code LO4100.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anzar Asad et al.
Basic & clinical pharmacology & toxicology, 133(4), 364-377 (2023-07-03)
Adhesion G protein-coupled receptors (GPCRs) are an underrepresented class of GPCRs in drug discovery. We previously developed an in vivo drug screening pipeline to identify compounds with agonist activity for Adgrg6 (Gpr126), an adhesion GPCR required for myelination of the
Laura M Alcântara et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-04)
High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be useful in enabling compound prioritization based on their spectrum
Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition
Tran UT and Kitami T
Communications biology, 2(1), 2-2 (2019)
High-throughput screening identifies compounds that enhance lentiviral transduction.
Johnston JM, Denning G, Moot R, et al.
Gene Therapy, doi:10-doi:10 (2014)
Jaime Freitas et al.
Current chemical genomics and translational medicine, 8, 36-46 (2014-04-29)
To adapt the use of GH3.TRE-Luc reporter gene cell line for a quantitative high-throughput screening (qHTS) platform, we miniaturized the reporter gene assay to a 1536-well plate format. 1280 chemicals from the Library of Pharmacologically Active Compounds (LOPAC) and the
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Articles

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

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