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850182P

Avanti

08:0 PI(4)P

Avanti Research™ - A Croda Brand

Synonym(s):

PIP[4′](8:0/8:0)

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About This Item

Empirical Formula (Hill Notation):
C25H54N2O16P2
CAS Number:
1246303-11-6
Molecular Weight:
700.65
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850182P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850182P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+]

General description

08:0 PIP is a phosphoinositol phosphate (PIP). Among prokaryotes, PI is synthesized by mycobacteria and few other bacterial genera.
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Application

08:0 PIP has been used to prepare multilamellar vesicle liposomes (MLV) for lipid binding assays. It is also suitable for use in the formation of protein-lipid tube and to examine fluorescence spectrum for analysing the PIP/sterol exchange properties of the Osh1 OSBP-related domain (ORD)

Biochem/physiol Actions

08:0 PIP can control ion channel activity. Phosphoinositol phosphates (PIPs) with short acyl chains, that are soluble in water can be used for reversible transport into the plasma membrane.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850182P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850182P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling
Sundborger A, et al.
Journal of Cell Science, 124(1), 133-143 (2011)
Short-chain phosphoinositide partitioning into plasma membrane models
Collins MD and Gordon SE
Biophysical Journal, 105(11), 2485-2494 (2013)
Intracellular traffic of the lysine and glutamic acid rich protein KERP1 reveals features of endomembrane organization in Entamoeba histolytica
Perdomo D, et al.
Cellular Microbiology, 18(8), 1134-1152 (2016)
Structure of yeast OSBP-related protein Osh1 reveals key determinants for lipid transport and protein targeting at the nucleus-vacuole junction
Manik MK, et al.
Structure, 25(4), 617-629 (2017)
Structural basis for phosphatidylinositol-phosphate biosynthesis
Clarke OB, et al.
Nature Communications, 6, 8505-8505 (2015)
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