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  • Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)
Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker
ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Platinum, gauze, 100 mesh, 99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum black, ≥99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, shot, ≤3 mm, ≥99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis
Pricing and availability is not currently available.
Sigma-Aldrich
Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis
Pricing and availability is not currently available.
Platinum, wire reel, 0.05m, diameter 0.6mm, as drawn, 99.99+%
Pricing and availability is not currently available.
Platinum, rod, 10mm, diameter 4.0mm, 99.95%
Pricing and availability is not currently available.
Platinum, insulated wire, 0.5m, conductor diameter 0.05mm, insulation thickness 0.0075mm, polyester insulation, 99.99%
Pricing and availability is not currently available.
Platinum, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.009mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Pricing and availability is not currently available.
Platinum, tube, 200mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%
Pricing and availability is not currently available.
Platinum, wire reel, 0.05m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%
Pricing and availability is not currently available.
Platinum, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%
Pricing and availability is not currently available.
Platinum, wire reel, 0.05m, diameter 1.0mm, as drawn, 99.99+%
Pricing and availability is not currently available.
Platinum, rod, 10mm, diameter 5.0mm, 99.95%
Pricing and availability is not currently available.
Platinum, tube, 200mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Pricing and availability is not currently available.
Platinum, rod, 50mm, diameter 1.25mm, 99.95%
Pricing and availability is not currently available.
Platinum, insulated wire, 2m, conductor diameter 0.05mm, insulation thickness 0.0075mm, polyester insulation, 99.99%
Pricing and availability is not currently available.
Platinum, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Pricing and availability is not currently available.
Platinum, rod, 10mm, diameter 2.0mm, 99.95%
Pricing and availability is not currently available.
Platinum, tube, 500mm, outside diameter 0.5mm, inside diameter 0.42mm, wall thickness 0.04mm, as drawn, 99.95%
Pricing and availability is not currently available.
Platinum, tube, 50mm, outside diameter 6mm, inside diameter 5.6mm, wall thickness 0.2mm, as drawn, 99.95%
Pricing and availability is not currently available.
Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%
Pricing and availability is not currently available.
Platinum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.5mm, wall thickness 0.05mm, as drawn, 99.95%
Pricing and availability is not currently available.