- Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.
Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.
Cancer letters (2012-10-04)
Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker
PMID23032720
ABSTRACT
One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.
MATERIALS
Product Number
Brand
Product Description
Platinum, rod, 50mm, diameter 1.25mm, 99.95%
Platinum, microfoil, disks, 25mm, thinness 0.1μm, specific density 120μg/cm2, permanent mylar 3.5μm support, 99.99%
Platinum, rod, 200mm, diameter 1.0mm, 99.95%
Platinum, insulated wire, 5m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyester insulation, 99.99%
Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%
Platinum, tube, 100mm, outside diameter 0.5mm, inside diameter 0.42mm, wall thickness 0.04mm, as drawn, 99.95%
Platinum, rod, 10mm, diameter 2.0mm, 99.95%
Platinum, tube, 100mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, rod, 25mm, diameter 1.0mm, 99.95%
Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%
Platinum, wire reel, 0.05m, diameter 0.6mm, as drawn, 99.99+%
Platinum, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.009mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Platinum, tube, 200mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%
Platinum, wire reel, 0.05m, diameter 1.0mm, as drawn, 99.99+%
Platinum, tube, 200mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.5mm, wall thickness 0.05mm, as drawn, 99.95%
Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%
Platinum, rod, 10mm, diameter 4.0mm, 99.95%
Platinum, tube, 200mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, tube, 500mm, outside diameter 0.5mm, inside diameter 0.42mm, wall thickness 0.04mm, as drawn, 99.95%
Platinum, wire reel, 0.05m, diameter 0.175mm, as drawn, 99.95%
Platinum, insulated wire, 2m, conductor diameter 0.05mm, insulation thickness 0.0075mm, polyester insulation, 99.99%
Platinum, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%
Platinum, rod, 2mm, diameter 2.0mm, 99.95%
Platinum, wire reel, 0.05m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 0.05m coil, thickness 0.030mm, coil width .7mm, as rolled, 99.95%
Platinum, wire reel, 0.05m, diameter 0.25mm, as drawn, 99.998%
Platinum, tube, 500mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%