SAB4500487

Anti-PARP (Cleaved-Asp²¹⁴) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): ADP-ribosyltransferase 1, ADPRT, ADPRT1, PARP, pADPRT-1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 24 kDa
• species reactivity: mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI accession no.: P09874
• UniProt accession no.: P09874
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: proteolytically cleaved (Asp214)
• Gene Information: human ... PARP1(142)

Description

General description

Anti-PARP (Cleaved-Asp²¹⁴) Antibody detects endogenous levels of fragment of activated PARP (Cleaved-Asp²¹⁴) protein.

PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear protein that consists of three functional domains. It belongs to the PARP family. It is located on chromosome 1q42.

Immunogen

The antiserum was produced against synthesized peptide derived from human PARP.

Immunogen Range: 165-214

Application

Anti-PARP (Cleaved-Asp214) antibody has been used in Western Blotting.

Biochem/physiol Actions

PARP1 (poly (ADP-ribose) polymerase 1) participates in DNA repair. It serves as a facilitator of homologous recombination. It controls transcription by regulating chromatin structure, altering DNA methylation patterns, acting as a co-regulator of transcription factors and interacting with chromatin insulators. It also plays an important role in the protection of cardiovascular system.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable