- Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step.
Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step.
The Journal of organic chemistry (2010-03-30)
Kiwon Han, Cheolwoo Kim, Jaiwook Park, Mahn-Joo Kim
PMID20345141
ABSTRACT
A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a lipase in combination as a key step. Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield.
MATERIALS