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  • [Distribution of 14C-phenazepam and its metabolites in the liver, brain and blood plasma in single and prolonged administration to white rats].

[Distribution of 14C-phenazepam and its metabolites in the liver, brain and blood plasma in single and prolonged administration to white rats].

Farmakologiia i toksikologiia (1980-03-01)
N Ia Golovenko, V G Zin'kovskiĭ, S B Seredenin, S A Andronati, L N Iakubovskaia
PMID6108232
ABSTRACT

The distribution pattern of 14C-phenazepam and some of its metabolites in the liver, brain and blood plasma at a prolonged (45 days) administration to rats does not differ from that after a single administration. The liver and brain demonstrated an increase in the content of 3-hydroxyderivative. Glycuronide was found only in the liver.