The role of iron and reactive oxygen species in cell death.

The role of iron and reactive oxygen species in cell death.

Nature chemical biology (2013-12-19)

Scott J Dixon, Brent R Stockwell

ABSTRACT

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are increasingly recognized as important initiators and mediators of cell death in a variety of organisms and pathological situations. Here, we review recent discoveries regarding the mechanism by which iron and ROS participate in cell death. We describe the different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form of iron-dependent cell death termed ferroptosis. Recent advances in understanding the role of iron and ROS in cell death offer unexpected surprises and suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.

MATERIALS

Product Number

Brand

Product Description

209309

Sigma-Aldrich

Iron, powder, −325 mesh, 97%

IRMM524B

Iron, IRMM^®, certified reference material, 0.5 mm wire

267945

Sigma-Aldrich

Iron, chips, 99.98% trace metals basis

356808

Sigma-Aldrich

Iron, foil, thickness 0.1 mm, ≥99.9% trace metals basis

44890

Sigma-Aldrich

Iron, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)

GF15174255

Iron, tube, 200mm, outside diameter 10.6mm, inside diameter 10.0mm, wall thickness 0.3mm, as drawn, 99.8+%

GF48235013

Iron, tube, 1000mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.5%

GF33764979

Iron, tube, 100mm, outside diameter 12.7mm, inside diameter 9.5mm, wall thickness 1.6mm, annealed, 99.5%

GF50403440

Iron, tube, 1000mm, outside diameter 12.0mm, inside diameter 10mm, wall thickness 1.0mm, annealed, 99.5%

GF89451737

Iron, tube, 200mm, outside diameter 25.0mm, inside diameter 21mm, wall thickness 2mm, annealed, 99.5%

GF95735571

Iron, tube, 1000mm, outside diameter 8.0mm, inside diameter 5mm, wall thickness 1.5mm, annealed, 99.5%

GF97078281

Iron, tube, 500mm, outside diameter 1.65mm, inside diameter 0.89mm, wall thickness 0.38mm, as drawn, 99.8+%

GF27258329

Iron, tube, 1000mm, outside diameter 12.0mm, inside diameter 9mm, wall thickness 1.5mm, annealed, 99.5%

GF70727801

Iron, tube, 200mm, outside diameter 3.18mm, inside diameter 1.96mm, wall thickness 0.61mm, as drawn, 99.5%

GF94244339

Iron, tube, 500mm, outside diameter 2.38mm, inside diameter 1.6mm, wall thickness 0.39mm, as drawn, 99.8+%

GF25366754

Iron, tube, 100mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.5%

GF16616897

Iron, tube, 1000mm, outside diameter 15.0mm, inside diameter 12mm, wall thickness 1.5mm, annealed, 99.5%

GF88344108

Iron, tube, 200mm, outside diameter 12.0mm, inside diameter 10mm, wall thickness 1.0mm, annealed, 99.5%

GF61545674

Iron, tube, 100mm, outside diameter 8.0mm, inside diameter 5mm, wall thickness 1.5mm, annealed, 99.5%

GF63891726

Iron, insulated wire, 10m, conductor diameter 0.25mm, insulation thickness 0.01mm, polyester insulation

GF17042082

Iron, tube, 200mm, outside diameter 4.0mm, inside diameter 3.6mm, wall thickness 0.2mm, as drawn, 99.5%

GF34939345

Iron, tube, 200mm, outside diameter 12.0mm, inside diameter 9mm, wall thickness 1.5mm, annealed, 99.5%

GF04812599

Iron, tube, 500mm, outside diameter 12.0mm, inside diameter 10mm, wall thickness 1.0mm, annealed, 99.5%

GF40975601

Iron, tube, 500mm, outside diameter 3.18mm, inside diameter 1.96mm, wall thickness 0.61mm, as drawn, 99.5%

GF06733818

Iron, tube, 200mm, outside diameter 5.0mm, inside diameter 4.5mm, wall thickness 0.25mm, as drawn, 99.5%

GF67418062

Iron, tube, 500mm, outside diameter 12.0mm, inside diameter 9mm, wall thickness 1.5mm, annealed, 99.5%

GF21950197

Iron, tube, 1000mm, outside diameter 3.18mm, inside diameter 1.96mm, wall thickness 0.61mm, as drawn, 99.5%

GF28189525

Iron, tube, 200mm, outside diameter 12.7mm, inside diameter 9.5mm, wall thickness 1.6mm, annealed, 99.5%

GF55674164

Iron, tube, 1000mm, outside diameter 5.0mm, inside diameter 4.5mm, wall thickness 0.25mm, as drawn, 99.5%

GF18645240

Iron, tube, 100mm, outside diameter 10.0mm, inside diameter 7mm, wall thickness 1.5mm, annealed, 99.5%