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  • Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives.

Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives.

Organic & biomolecular chemistry (2012-01-28)
Akihiro Ohkubo, Yudai Nishino, Yu Ito, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
PMID22281690
ABSTRACT

In this paper, we report DNA and 2'-OMe-RNA probes containing 5-methyl-2-thiocytidine (m(5)s(2)C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group.