- Concise total synthesis of (-)-8-epigrosheimin.
Concise total synthesis of (-)-8-epigrosheimin.
Organic letters (2011-06-17)
Haishen Yang, Yuzhe Gao, Xiaoxiao Qiao, Longguan Xie, Xiaohua Xu
PMID21675754
ABSTRACT
A highly efficient route was developed to synthesize (-)-8-epigrosheimin in four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.
MATERIALS
Product Number
Brand
Product Description
Supelco
(+)-Carvone, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland