- Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment.
Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment.
Nucleosides, nucleotides & nucleic acids (2005-10-27)
Fernando Ferreira, François Morvan
PMID16248081
ABSTRACT
An oligonucleotide protected with N-(trimethylsilyloxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups was synthesized and deprotected by a single ZnBr2 treatment. Finally it was released from the solid support by cleavage of a disulfide linkage with TCEP. The olgonucleotide was obtained without any basic treatment.