- Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow.
Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow.
Methods in molecular biology (Clifton, N.J.) (2017-12-22)
Teresa Massam-Wu, Stuart A Cain, Cay M Kielty
PMID29264810
ABSTRACT
We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, through integrin receptors, with their ECM. The system offers an insight into how MSCs could be targeted/localized to the site of interest (graft) following intravenous injection.
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