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P9159

Sigma-Aldrich

Piperidine-4-sulfonic acid

Synonym(s):

P4S

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About This Item

Empirical Formula (Hill Notation):
C5H11NO3S
CAS Number:
72450-62-5
Molecular Weight:
165.21
MDL number:
MFCD00055097
UNSPSC Code:
12352106
PubChem Substance ID:
24278165
NACRES:
NA.77

form

powder

SMILES string

OS(=O)(=O)C1CCNCC1

InChI

1S/C5H11NO3S/c7-10(8,9)5-1-3-6-4-2-5/h5-6H,1-4H2,(H,7,8,9)

InChI key

UGBJGGRINDTHIH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Biochem/physiol Actions

GABAA receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Angelo Keramidas et al.
The Journal of physiology, 575(Pt 1), 11-22 (2006-06-10)
The binding of the neurotransmitter GABA induces conformational changes in the GABAA receptor (GABAAR), leading to the opening of a gate that controls ion permeation through an integral transmembrane pore. A number of structural elements within each subunit, located near
Ko Ko et al.
Journal of medical virology (2020-06-25)
This study aimed to investigate the prevalence trend of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and their genotype distribution among hemodialysis patients, determining their long-term prognosis and the risk factors to the mortality. This cohort study
J W Miller et al.
Epilepsia, 34(6), 973-978 (1993-11-01)
The cerebellum is electrically and metabolically active during seizures. Numerous studies have also shown that cerebellar electrical stimulation and lesions of the cerebellar cortex or nuclei influence seizure threshold, but there are significant contradictions, with different effects observed even in
S M O'Shea et al.
Brain research, 852(2), 344-348 (2000-03-11)
Using the whole-cell patch-clamp technique, we have determined that propofol, but not midazolam, increases the efficacy of piperidine-4-sulphonic acid (P4S), a partial agonist at alpha1beta1gamma2s, GABA(A) receptors expressed in HEK 293 cells. These findings are consistent with the idea that
Marc C Gielen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(17), 5707-5715 (2012-04-28)
GABA(A) receptors (GABA(A)Rs) composed of αβγ subunits are allosterically modulated by the benzodiazepines (BDZs). Agonists at the BDZ binding site potentiate submaximal GABA responses by increasing the apparent affinity of GABA(A)Rs for GABA. Although BDZs were initially thought to affect
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