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372770

Sigma-Aldrich

HBDDE

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.

Synonym(s):

HBDDE, 2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether

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About This Item

Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
154675-18-0
Molecular Weight:
338.31
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

ethanol: 1 mg/mL
warm water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3

InChI key

NEBCAMAQXZIVRE-UHFFFAOYSA-N

General description

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI, and βII isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.
Protein kinase C (PKC) inhibitor. Selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI and βII isozymes.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKCα
Product does not compete with ATP.
Reversible: no
Target IC50: 43 µM against PKCα

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol.60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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