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Merck

HTR1B

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

Synonyms:
5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Species:
Human HTR1B (3351), Mouse Htr1b (15551), Rat Htr1b (25075), chicken HTR1B (421858), Zebrafish htr1b (561647), dog HTR1B (403741), cow HTR1B (317707), Horse HTR1B (100009680), domestic cat HTR1B (100144391), Domestic Rabbit HTR1B (100009594) ...More
UniProtKB ID:
P28222, Q4VAY7
Gene ID:
  • Human(3351) Summary: The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]
  • Mouse(15551) 5-hydroxytryptamine (serotonin) receptor 1B
  • Rat(25075) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • chicken(421858) 5-hydroxytryptamine (serotonin) receptor 1B
  • Zebrafish(561647) 5-hydroxytryptamine (serotonin) receptor 1B
  • dog(403741) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • cow(317707) 5-hydroxytryptamine (serotonin) receptor 1B
  • Horse(100009680) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • domestic cat(100144391) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • Domestic Rabbit(100009594) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • sheep(101111375) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • domestic guinea pig(100135543) 5-hydroxytryptamine (serotonin) receptor 1B

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Small Molecule - Agonist

Product Number
Description
Species
N1415
Naratriptan hydrochloride, ≥98% (HPLC),
Species
human
1457469
Naratriptan hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Y0000027
Sumatriptan for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
S1198
Sumatriptan succinate, ≥98% (HPLC), solid,
Species
human
SML0248
Zolmitriptan, ≥98% (HPLC),
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
D9190
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
G5793
GR 127935 hydrochloride hydrate, >98% (HPLC), powder,
Species
human
M149
Methiothepin mesylate salt, ≥98% (HPLC), solid,
Species
human
P8688
(S)-(−)-Propranolol hydrochloride, ≥98% (TLC), powder,
Species
human
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
M137
Methysergide maleate salt, solid,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB4501470
Anti-5-HT-1B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
SAB4501471
Anti-HTR1B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
SAB2500924
Anti-Serotonin Receptor 1B/HTR1B antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
MABN1539
Anti-Serotonin Receptor 1B Antibody, clone 1C2.1, clone 1C2.1, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
P8688
(S)-(−)-Propranolol hydrochloride, ≥98% (TLC), powder,
Species
human
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
T3146
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Z101
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
F1553
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Species
human
F1678
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Species
human
S6319
Sertraline hydrochloride, ≥98% (HPLC),
Species
human
F2802
Fluvoxamine maleate, solid,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Precursor

Product Number
Description
Species
H9772
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
EMU044151
MISSION® esiRNA, targeting mouse Htr1b,
Species
mouse