- Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype.
Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype.
Journal of neuroimmunology (2016-12-25)
Andreas Warnecke, Sravani Musunuri, Marie N'diaye, Tatyana Sandalova, Adnane Achour, Jonas Bergquist, Robert A Harris
PMID28011088
ABSTRACT
Post-translational modifications of autoantigens are hypothesized to affect their immunogenicity. We here report that nitration of tyrosine 40 in Myelin Oligodendrocyte Glycoprotein (MOG) abrogates its encephalitogenicity both at protein and peptide levels in the experimental autoimmune encephalomyelitis (EAE) model in H2
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Anti-Nitrotyrosine antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution