- Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney.
Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney.
Scientific reports (2017-02-24)
Carmen De Miguel, William C Hamrick, Janet L Hobbs, David M Pollock, Pamela K Carmines, Jennifer S Pollock
PMID28230089
ABSTRACT
Endothelin-1 (ET-1) promotes renal damage during cardiovascular disease; yet, the molecular mechanisms involved remain unknown. Endoplasmic reticulum (ER) stress, triggered by unfolded protein accumulation in the ER, contributes to apoptosis and organ injury. These studies aimed to determine whether the ET-1 system promotes renal ER stress development in response to tunicamycin. ET
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